Peripheral Leukocyte Kinetic Studies of Acute Leukemia in Relapse and Remission and Chronic Myelocytic Leukemia in Blastic Crisis

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Peripheral Leukocyte Kinetic Studies of Acute Leukemia in Relapse and Remission and Chronic Myelocytic Leukemia in Blastic Crisis

I T HAS BEEN ONLY RECENTLY that significant progress has been made in the study of leukocyte kinetics and cell proliferation in acute leukemia. This became possible with the introduction of tritiated thymidine (H3TdR), a labeled precursor specffic for DNA.’ With the technic of radioautography, this labeled compound has been employed in vivo to investigate the leukemic cell cycle and cell prolif...

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Peripheral leukocyte kinetic studies of acute leukemia in relapse and remission and chronic myelocytic leukemia in blastic crisis.

I T HAS BEEN ONLY RECENTLY that significant progress has been made in the study of leukocyte kinetics and cell proliferation in acute leukemia. This became possible with the introduction of tritiated thymidine (H3TdR), a labeled precursor specffic for DNA.’ With the technic of radioautography, this labeled compound has been employed in vivo to investigate the leukemic cell cycle and cell prolif...

متن کامل

Peripheral Leukocyte Kinetic Studies of Acute Leukemia in Relapse and Remission and Chronic Myelocytic Leukemia in Blastic Crisis

I T HAS BEEN ONLY RECENTLY that significant progress has been made in the study of leukocyte kinetics and cell proliferation in acute leukemia. This became possible with the introduction of tritiated thymidine (H3TdR), a labeled precursor specffic for DNA.’ With the technic of radioautography, this labeled compound has been employed in vivo to investigate the leukemic cell cycle and cell prolif...

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Blastic crisis and myelofibrosis, simultaneous complications in a case of chronic myelocytic leukemia.

A case of chronic myelocytic leukemia is reported. He developed blastic crisis as well as myelofibrosis, simultaneously as a complication, after 1-1/2 years treatment with myeleran.

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Ultrastructural cytochemical analysis of blastic transformation of chronic myelocytic leukemia.

Ultrastructural cytochemical changes occurring during the blast phase of chronic myelocytic leukemia (CML) are described. Normal developing promyelocytes contain myeloperoxidase (MPO) -positive rough endoplasmic reticulum, nuclear envelope, and Golgi apparatus. All secretory granules of normal promyelocytes are also MPO-positive. In this study we have found abnormal promyelocytes with MPO-posit...

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ژورنال

عنوان ژورنال: Blood

سال: 1968

ISSN: 0006-4971,1528-0020

DOI: 10.1182/blood.v31.6.686.686